dont get some gunowner attitudes

[FIVETWOSEVEN]

If they aren't in the middle of an adrenaline rush or on drugs

No gun will stop someone with a single shot reliably, one shot from a .25 to the central nervous system will stop someone, in their tracks, high or sober. This is the same with any gun.

Once read a story about a cop that shot someone high on drugs 6 times with a .41 magnum revolver and that didn't even stop him.

Shot placement > Caliber.