I'm a lefty and have no problem operating any handgun. Left index finger hits the mag release, right hand grabs a fresh mag off your belt and insert it into magwell, right hand slingshots the slide and quickly reacquire target. I compete in pistol competitions and 3-gun and with practice being a lefty is only a minor inconvenience. I also have experience with both the Sig and the Beretta. And while I realize that under fire your stress level can alter things but if you can count your shots or reload when convenient you can take out the whole step of slingshoting the slide.
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