I always heard good things about the S&W 1006. Built like a boat anchor. Not meant to be a CCW pistol, but very solid. I own a second generation S&W Model 745 and that's one solid pistol. Again pretty massive, but I didn't buy it to carry on my ankle.

OMG I want a S&W 1006/1076, looks just like the 4506 but in the bear killing 10mm, not the obsolete .45 ACP!!!

You could probably carry a Glock 29 on your ankle. But that would be pretty hard to handle in a live-fire situation without lots of practice.

S&W is largely out of the business of making handguns in that caliber. You might want to try the newer SIG P220 in 10mm instead.

The SIG P220 in 10mm for $1400, no thank you. The S&W 10mms are usually in the 7-900 dollar range and the Glock 20/29 isn't meant to fire the full power 10mms unless you fork out the money for an aftermarket barrel with a fully supported chamber. the S&W 1006/1076/1066 are one of the few 10mm pistols from what I understand can run full power loads in their factory configuration.

Actually all you need for the 10mm Glock to shoot better is a stronger guide rod and that's it. A buddy of mine has one as his carry gun

A Glock's price point that ain't. You could go get a Rock Island Armoury in M1911 in 10mm instead.

The 10mm Glocks can fire full-power 10mm loads with their stock barrels, it's just that the brass ejected will be bulged, which means it can't be reused for handloading (though of course it can still be melted back down to be recycled). The unsupported part of the chamber in stock Glock barrels is to increase feeding reliability, but this obviously has its drawbacks with regards to higher-pressure cartridges. Given the ubiquity of Glocks, however, finding conversion barrels at reasonable prices shouldn't be too difficult. The S&W 1006 series is also made on single-stack frames, and that means you get stock with single-stack magazine capacities which you can't increase by much afterwards.

.45 Super, man. If I had a spare 4506, I'd look into it

I don't really have a need for 10mm; reckon having a .45 that'll eat +P+ indefinitely will do whatever I'd need a 10mm for

Is that something that I'd need to have the gunsmith do? Also I have the 4506-0

The two rounds are externally exactly the same size, I imagine the only difference that you would need would be a stiffer recoil spring. There are also a few other parts that I imagine it would be a good idea to upgrade, but I think the recoil spring would be the only thing that you would really have to change. Thinking about it, I imagine that a spring meant for a 1006 would probably do.

I've done a little bit of reading and a lot of people recommend some kind of upgrade kit specifically talking about a recoil buffer or something like that, something along the lines of it being needed or .45 super will wear the gun out faster -and being that the 4506 is no longer supported by S&W that would suck